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FOXO1 — PDK4
Text-mined interactions from Literome
Nahlé et al., J Biol Chem 2008
:
FoxO1 in turn can
regulate CD36, lipoprotein lipase, and
PDK4 , reinforcing the action of PPARdelta/beta to increase muscle reliance on FA
Piao et al., J Mol Med (Berl) 2013
(Hypertension, Pulmonary...) :
We hypothesize that
FOXO1 mediated
PDK4 upregulation causes bioenergetic impairment and RV dysfunction, which can be reversed by dichloroacetate ... Chronic dichloroacetate inhibits
FOXO1 induced
PDK4 upregulation and restores GO, leading to improved bioenergetics and RV function in RVH