Gene interactions and pathways from curated databases and text-mining

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FOXO1 — PDK4

Text-mined interactions from Literome

Nahlé et al., J Biol Chem 2008 : FoxO1 in turn can regulate CD36, lipoprotein lipase, and PDK4 , reinforcing the action of PPARdelta/beta to increase muscle reliance on FA
Piao et al., J Mol Med (Berl) 2013 (Hypertension, Pulmonary...) : We hypothesize that FOXO1 mediated PDK4 upregulation causes bioenergetic impairment and RV dysfunction, which can be reversed by dichloroacetate ... Chronic dichloroacetate inhibits FOXO1 induced PDK4 upregulation and restores GO, leading to improved bioenergetics and RV function in RVH