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FOXO1 — PDX1
Text-mined interactions from Literome
Kitamura et al., J Clin Invest 2002
(Diabetes Mellitus, Type 2) :
We propose that insulin/IGFs regulate beta cell proliferation by relieving
Foxo1 inhibition of
Pdx1 expression in a subset of cells embedded within pancreatic ducts
Kawamori et al., J Biol Chem 2006
:
Furthermore, adenovirus mediated
Foxo1 overexpression
reduced the nuclear expression of
PDX-1 , whereas repression of Foxo1 by Foxo1-specific small interfering RNA retained the nuclear expression of PDX-1 under oxidative stress conditions ... Taken together,
Foxo1 is
involved in the nucleocytoplasmic translocation of
PDX-1 by oxidative stress and the JNK pathway
Fan et al., Diabetes Obes Metab 2010
(Diabetes Mellitus, Type 2) :
Moreover, hIAPP induced
FOXO1 but
inhibited pdx-1 nucleus translocation
Meur et al., J Biol Chem 2011
:
We conclude that nuclear import of
FoxO1 contributes to the suppression of
Pdx1 and Ins2 gene expression at low glucose, the latter via a previously unsuspected and direct physical interaction with the Ins2 promoter