Gene interactions and pathways from curated databases and text-mining

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FOXO1 — PDX1

Text-mined interactions from Literome

Kitamura et al., J Clin Invest 2002 (Diabetes Mellitus, Type 2) : We propose that insulin/IGFs regulate beta cell proliferation by relieving Foxo1 inhibition of Pdx1 expression in a subset of cells embedded within pancreatic ducts
Kawamori et al., J Biol Chem 2006 : Furthermore, adenovirus mediated Foxo1 overexpression reduced the nuclear expression of PDX-1 , whereas repression of Foxo1 by Foxo1-specific small interfering RNA retained the nuclear expression of PDX-1 under oxidative stress conditions ... Taken together, Foxo1 is involved in the nucleocytoplasmic translocation of PDX-1 by oxidative stress and the JNK pathway
Fan et al., Diabetes Obes Metab 2010 (Diabetes Mellitus, Type 2) : Moreover, hIAPP induced FOXO1 but inhibited pdx-1 nucleus translocation
Meur et al., J Biol Chem 2011 : We conclude that nuclear import of FoxO1 contributes to the suppression of Pdx1 and Ins2 gene expression at low glucose, the latter via a previously unsuspected and direct physical interaction with the Ins2 promoter