Gene interactions and pathways from curated databases and text-mining

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PDX1 — SST

Text-mined interactions from Literome

Itkin-Ansari et al., Mol Endocrinol 2000 : This is the first report of induction of the endogenous somatostatin gene by PDX-1
Miyazaki et al., Diabetes 2004 : The results showed that pdx-1 expression clearly enhanced the expression of the insulin 2, somatostatin , Kir6.2, glucokinase, neurogenin3, p48, Pax6, PC2, and HNF6 genes in the resulting differentiated cells
Linning et al., Pancreas 2004 : Overexpression of Pdx-1 in HPC cultures stimulated somatostatin , glucagon, and carbonic anhydrase expression but had no effect on insulin gene expression
Stanojevic et al., Mol Cell Endocrinol 2005 : Transcriptional activation by PDX-1 is increased by addition of Bridge-1 in multiple contexts, including synergistic activation of a Gal4 reporter by Gal4-Bridge-1 and Gal4-PDX-1 fusion proteins, activation of the somatostatin promoter TAAT1 enhancer, and synergistic activation of the rat insulin I promoter FarFlat enhancer by PDX-1 , E12, and E47
Danso-Abeam et al., Eur J Immunol 2013 : Surprisingly, we found that lack of Pdx1 in TECs did not reduce the transcription of insulin or somatostatin , or alter glucagon expression