◀ Back to SST
PDX1 — SST
Text-mined interactions from Literome
Itkin-Ansari et al., Mol Endocrinol 2000
:
This is the first report of
induction of the endogenous
somatostatin gene by
PDX-1
Miyazaki et al., Diabetes 2004
:
The results showed that
pdx-1 expression clearly
enhanced the expression of the insulin 2,
somatostatin , Kir6.2, glucokinase, neurogenin3, p48, Pax6, PC2, and HNF6 genes in the resulting differentiated cells
Linning et al., Pancreas 2004
:
Overexpression of
Pdx-1 in HPC cultures
stimulated somatostatin , glucagon, and carbonic anhydrase expression but had no effect on insulin gene expression
Stanojevic et al., Mol Cell Endocrinol 2005
:
Transcriptional activation by PDX-1 is increased by addition of Bridge-1 in multiple contexts, including synergistic activation of a Gal4 reporter by Gal4-Bridge-1 and Gal4-PDX-1 fusion proteins,
activation of the
somatostatin promoter TAAT1 enhancer, and synergistic activation of the rat insulin I promoter FarFlat enhancer by
PDX-1 , E12, and E47
Danso-Abeam et al., Eur J Immunol 2013
:
Surprisingly, we found that lack of
Pdx1 in TECs did not
reduce the transcription of insulin or
somatostatin , or alter glucagon expression