Gene interactions and pathways from curated databases and text-mining

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FOXO1 — PGC

Text-mined interactions from Literome

Daitoku et al., Diabetes 2003 : Coexpression of FKHR stimulates the PGC-1 promoter activity via interaction with the IRSs, while coexpression of FKHR ( 3A ), in which the three putative PKB sites in FKHR are mutated, mainly abolishes the suppressive effect of PKB
Geng et al., Am J Pathol 2011 (Cachexia) : PGC-1a promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice
Felder et al., J Biol Chem 2011 : Here we describe a novel human liver-specific PGC-1a transcript that results from alternative promoter usage and is induced by FOXO1 as well as glucocorticoids and cAMP-response element binding protein signaling but is not present in other mammals