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PGC — PRKAA1

Text-mined interactions from Literome

Lee et al., Biochem Biophys Res Commun 2006 : Here we show that AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) increases mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle, and that inhibition of PPARalpha and PGC-1 by siRNAs prevents AICAR stimulated increase in fatty acid oxidation
Lira et al., J Physiol 2010 : Nitric oxide and AMPK cooperatively regulate PGC-1 in skeletal muscle cells
Łabuzek et al., Pharmacol Rep 2010 : Furthermore, the effects of metformin on the release of IL-1ß, IL-6, IL-10, TGF-ß, NO, and ROS as well as on the expression of arginase I, iNOS, NF-?B p65 and PGC-1a were not AMPK dependent , because pretreatment of LPS activated microglia with compound C, a pharmacological inhibitor of AMPK, did not reverse the effect of metformin
Beharry et al., Proc Natl Acad Sci U S A 2011 : Overexpression of PGC-1a in TKO MEFs elevated ATP levels and inhibited the activation of AMPK
Birkenfeld et al., Cell Metab 2011 (Insulin Resistance...) : Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio, activates hepatic AMPK , induces PGC-1a , inhibits ACC-2, and reduces SREBP-1c levels
Norrbom et al., Am J Physiol Endocrinol Metab 2011 : AMPK phosphorylation increased to a greater extent in the R-leg, and AICAR stimulation of cultured human myotubes induced the expression of PGC-1a-a and PGC-1a-b
Smith et al., J Physiol 2013 : These data suggest that exercise causes translocation of PGC-1a preferentially to SS mitochondria in an AMPK dependent manner
Wang et al., Int J Biochem Cell Biol 2013 : Erythropoietin also increases AMPK , which induces PGC-1a and stimulates slow oxidative fiber formation