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CXCL2 — PGF
Text-mined interactions from Literome
Wallace et al., Cancer Res 2009
(Adenocarcinoma...) :
This study found that
PGF ( 2alpha ) signaling via FP
regulates expression of
chemokine ( C-X-C motif ) ligand 1 ( CXCL1 ) in endometrial adenocarcinoma cells
Sales et al., Biochim Biophys Acta 2009
(Adenocarcinoma...) :
We found that
PGF ( 2alpha ) -FP receptor interaction
induces CXCL8 expression in endometrial adenocarcinoma cells via the protein kinase C-calcium-calcineurin-NFAT signaling pathway ... Promoter analysis revealed that
CXCL8 transcriptional
activation by
PGF ( 2alpha ) signaling is mediated by cooperative interactions between the AP1 and NFAT binding sites ... Taken together our data have elucidated the molecular and cellular mechanism whereby
PGF ( 2alpha )
regulates CXCL8 expression via the FP receptor in endometrial adenocarcinomas and have highlighted RCAN1-4 as a negative regulator of CXCL8 expression which may be exploited therapeutically to inhibit CXCL8 mediated tumour development