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CHUK — PI3

Text-mined interactions from Literome

Das et al., J Biol Chem 2003 (Breast Neoplasms) : However, both pharmacological ( wortmannin and LY294002 ) and genetic ( Deltap85 ) inhibitors of PI 3'-kinase inhibited OPN induced Akt phosphorylation, IKK activity, and NFkappaB activation through phosphorylation and degradation of IkappaBalpha
Bhattacharyya et al., Blood 2004 : Furthermore, IL-10 blocked inducible Akt phosphorylation, and inhibitors of phosphatidylinositol 3-kinase (PI3K) effectively suppressed the activation of Akt, IKK , and NF-kappaB
Volanti et al., Oncogene 2005 (Neoplasms) : In T24, NF-kappaB activation occurs through a protein kinase C (PKC)alpha- and phosphoinositide-3-kinase (PI3K) dependent I kappa B kinase (IKK) complex activation, whereas in HeLa cells, NF-kappaB activation is mediated by PKC- and PI3K independent IKK complex activation
Ouyang et al., Carcinogenesis 2006 (Skin Neoplasms) : Furthermore, inhibition of PI-3K/Akt by overexpression of Deltap85 or DN-Akt blocked arsenite induced IKK phosphorylation, IkappaBalpha degradation and cyclin D1 expression, indicating that IKK/NFkappaB is the downstream transducer of arsenite triggered PI-3K/Akt cascade