Gene interactions and pathways from curated databases and text-mining

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KLF4 — PI3

Text-mined interactions from Literome

Zheng et al., J Biol Chem 2009 : We demonstrated that Klf4 directly binds to the 5 ' regulatory region of RAR alpha, down-regulates RAR alpha expression, and specifically inhibits RAR alpha mediated phosphatidylinositol 3-kinase (PI3K) and ERK signaling in cultured VSMCs induced by the synthetic retinoid Am80
Ghosh et al., J Biol Chem 2012 (Neurodegenerative Diseases) : This study delineates a novel property of gemfibrozil in up-regulating SOCS3 in glial cells via PI 3-kinase-AKT mediated activation of KLF4 and suggests that gemfibrozil may find therapeutic application in neuroinflammatory and neurodegenerative disorders