Gene interactions and pathways from curated databases and text-mining

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PLAU — TIMP1

Text-mined interactions from Literome

Shibata et al., J Periodontol 1999 : TIMP-1 controls the synthesis of uPA in the PDL cells
Festuccia et al., Anticancer Res 2000 (Prostatic Neoplasms) : High levels of TIMP1 and PAI1 present in S variant reduce MMP9 and uPA activities, respectively
Gillette et al., Tumori 2003 : We detected MMP-7, urokinase plasminogen activator (uPA) and PAI-1 in both Matrigels, TIMP-2 was detected only in regular Matrigel and no MMP-1 or TIMP-1 was detected in either matrix
Eddy et al., Kidney Int 1998 (Fibrosis...) : Compared with the untreated hypercholesterolemic group, antioxidant therapy induced significant reductions in renal mRNA levels for procollagen III ( to 60 % of untreated levels ), collagen IV ( 60 % ), and TIMP-1 ( 20 % ), while uPA levels were significantly increased ( to 210 % )