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MAPK6 — PLCG1

Text-mined interactions from Literome

Kornmann et al., Gastroenterology 2002 (Cell Transformation, Neoplastic...) : In vitro, TAKA-1 cells stably transfected with FGFR-1 IIIc exhibited increased basal growth ; enhanced basal tyrosine phosphorylation of FGFR substrate-2 (FRS2), Shc, and phospholipase Cgamma ; and increased activation of mitogen activated protein kinase ( MAPK )
Chen et al., J Biol Chem 2002 : Incubation of cells with the specific EGFR inhibitor AG4178 blocked MbetaCD induced phosphorylation of EGFR, SHC, phospholipase C-gamma , and Gab-1 as well as MAPK activation
Kwon et al., J Cell Biol 2003 : Expression of the PH-EF construct blocked endogenous PLCgamma1 binding to the IR and inhibited insulin dependent phosphorylation of mitogen activated protein kinase ( MAPK ), but not AKT ... Silencing PLCgamma1 expression using small interfering RNA markedly reduced insulin dependent MAPK regulation in HepG2 cells
Rong et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Here, we report that the phospholipase activity of PLC-gamma1 plays an essential role in nerve growth factor (NGF) triggered Raf/MEK/MAPK pathway activation in PC12 cells ... These observations indicate that the lipase activity of PLC-gamma1 mediates NGF regulated MAPK signaling upstream of Ras/Rap1 activation probably through second messenger DAG activated Ras and Rap-GEFs
Luo et al., J Clin Invest 2004 : Further downstream, in the absence of EphB6, ZAP-70 activation, LAT phosphorylation, the association of PLCgamma1 with SLP-76, and p44/42 MAPK activation were diminished
Shen et al., J Mol Cell Cardiol 2007 : PLCgamma1 activation by LPS also increased ERK1/2 MAPK phosphorylation, and inhibition of ERK1/2 MAPK blocked the effect of PLCgamma1 on COX-2 expression
Zheng et al., J Neurochem 2008 (Ion Channel Gating) : Although previous studies suggested the roles of mitogen activated protein kinase , phospholipase C-gamma mediated intracellular calcium ( [ Ca2+ ] i ) increase , and extracellular calcium influx in regulating Akt activation, the cellular mechanisms are largely unknown
Marra et al., J Clin Invest 1996 : IFN-gamma pretreatment did not influence PDGF or EGF receptor autophosphorylation, activation of phospholipase Cgamma1 , and phosphatidylinositol 3-kinase, or mitogen activated protein kinase activity