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EDN1 — PLD1

Text-mined interactions from Literome

Le Stunff et al., J Pharmacol Exp Ther 2000 : The roles of protein kinase C and tyrosine kinases in mediating endothelin-1 stimulated phospholipase D activity in rat myometrium : differential inhibition by ceramides and cyclic AMP ... The aim of the present study was to investigate the mechanisms that regulate the activation of phospholipase D ( PLD ) by endothelin (ET)-1 in rat myometrium
Hess et al., Cell Signal 2000 : Altered activation of phospholipase D by lysophosphatidic acid and endothelin-1 in mouse embryo fibroblasts lacking phospholipase C-gamma1 ... Lysophosphatidic acid (LPA) and endothelin-1 (ET-1) activate phospholipase D ( PLD ) in many cell types
Coletti et al., Exp Cell Res 2000 : Vesicle traffic with similar features was also observed after endothelin-1 induced PC-PLD activation in rat peritubular myoid cells
Shome et al., Endocrinology 2000 : The activation of PLD in these cells by angiotensin II ( AngII ), endothelin-1 (ET-1), and platelet derived growth factor ( PDGF ) was found to be sensitive to inhibitors of the activation of ADP-ribosylation factor ( ARF ) but not to blockers of Rho protein function ... The activation of PLD in these cells by angiotensin II ( AngII ), endothelin-1 (ET-1) , and platelet derived growth factor ( PDGF ) was found to be sensitive to inhibitors of the activation of ADP-ribosylation factor ( ARF ) but not to blockers of Rho protein function
Fahimi-Vahid et al., J Mol Cell Cardiol 2002 : Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin
Zhang et al., Cell Signal 1992 : Activation of phospholipase D by endothelin-1 and other pharmacological agents in rabbit iris sphincter smooth muscle ... The stimulation of phospholipase D ( PLD ) activity by endothelin-1 (ET1) was investigated in rabbit iris sphincter prelabelled with [ 3H ] myristic acid
Kester et al., J Cell Physiol 1992 : In addition, endothelin stimulated the release of 3H-choline and 3H-ethanolamine, demonstrating that additional phospholipids may serve as substrates for phospholipase D. Phorbol esters and synthetic diglycerides mimicked the effects of endothelin to stimulate phospholipase D and inhibitors of protein kinase C significantly reduced endothelin stimulated phospholipase D ... The calcium ionophore, ionomycin, did not stimulate phospholipase D and mesangial cells pretreated with BAPTA to chelate cytosolic calcium did not show a diminished endothelin stimulated phospholipase D
van der Bend et al., Biochem J 1992 : Our results indicate that : ( 1 ) LPA is less efficient than endothelin in inducing phosphoinositide and PC breakdown ; ( 2 ) LPA induced PLD activation is short lived, levelling off after 2 min, whereas the endothelin stimulated increase in PLD activity persists for at least 1 h ; ( 3 ) the effect of LPA on PLD, like that of endothelin, is blocked by long-term pretreatment of the cells with phorbol ester, suggesting that PLD activation occurs through a protein kinase C-dependent mechanism
Pai et al., Cell Regul 1991 : Endothelin-1 activates phospholipase D and thymidine incorporation in fibroblasts overexpressing protein kinase C beta 1
Sarri et al., J Neurochem 1995 : Histamine H1 and endothelin ETB receptors mediate phospholipase D stimulation in rat brain hippocampal slices ... Among the six neurotransmitter receptor agonists tested, only noradrenaline, histamine, endothelin-1 , and trans-ACPD stimulated phospholipase D in hippocampus and cortex, an effect that was strictly dependent of the presence of millimolar extracellular calcium concentrations ... Among the six neurotransmitter receptor agonists tested, only noradrenaline, histamine, endothelin-1 , and trans-ACPD stimulated phospholipase D in hippocampus and cortex, an effect that was strictly dependent of the presence of millimolar extracellular calcium concentrations ... Endothelin-1 stimulated phospholipase D ( EC50 44 nM ) was not blocked by BQ-123, a specific antagonist of the ETA receptor ... These results show that histamine and endothelin-1 stimulate phospholipase D in rat brain through H1 and ETB receptors, respectively
Suzuki et al., Mol Cell Endocrinol 1994 : Effect of endothelin-1 on phospholipase D activity in osteoblast-like cells
Plevin et al., Br J Pharmacol 1994 (Anoxia) : Regulation by hypoxia of endothelin-1 stimulated phospholipase D activity in sheep pulmonary artery cultured smooth muscle cells
Ambar et al., Eur J Pharmacol 1993 (Glioma) : The activation of PLC or PLD by endothelin in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+
Wilkes et al., FEBS Lett 1993 : Endothelin-1 stimulated phospholipase D in A10 vascular smooth muscle derived cells is dependent on tyrosine kinase
Dokhac et al., J Cardiovasc Pharmacol 1995 : In estrogen treated rat myometrium, endothelin-1 (ET-1) activated both the phospholipase C (PLC) which degrades PtdInsP2, resulting in an increased accumulation of inositol phosphates, and the phospholipase D pathway ( PLD ) as evidenced in the presence of butanol by an increased production of phosphatidylbutanol ( PBut )
Nord et al., Clin Exp Pharmacol Physiol 1996 : 4. Activation by endothelin of phosphatidylcholine-specific phospholipase D is under the dual regulation of protein kinase C and [Ca2+ ] i, with protein kinase C being the major regulator and [Ca2+ ] i playing a secondary, modulatory role