Gene interactions and pathways from curated databases and text-mining

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FOXO1 — POMC

Text-mined interactions from Literome

Yang et al., J Biol Chem 2009 : FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
Iskandar et al., Am J Physiol Endocrinol Metab 2010 (Obesity) : Although expression of the CNFoxO1 made POMCPdk1 ( -/- ) mice more obese due to excessive suppression of Pomc gene, overexpression of Delta256FoxO1 in POMC neurons had no effects on metabolic phenotypes and Pomc expression levels of POMCPdk1 ( -/- ) mice ... These data suggest a requirement for PDK-1 and FoxO1 in transcriptional regulation of Pomc and food intake