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NEDD4L — PRKAB1

Text-mined interactions from Literome

Bhalla et al., J Biol Chem 2006 : AMPK dependent phosphorylation of Nedd4-2 expressed in HEK-293 cells occurred both in vitro and in vivo, suggesting a potential mechanism for modulation of Nedd4-2 and thus cellular ENaC activity ... In summary, these results suggest a novel mechanism for ENaC regulation in which AMPK promotes ENaC-Nedd4-2 interaction, thereby inhibiting ENaC by increasing Nedd4-2 dependent ENaC retrieval from the plasma membrane
Alzamora et al., American journal of physiology. Renal physiology 2010 : As it has been recently shown that the ubiquitin-protein ligase Nedd4-2 inhibits KCNQ1 plasma membrane expression and that AMPK regulates epithelial Na ( + ) channels via Nedd4-2, we examined the role of Nedd4-2 in the AMPK dependent regulation of KCNQ1
Andersen et al., Traffic 2012 : In summary, surface expressed Kv7.1 channels are endocytosed and sent for degradation in lysosomes by an AMPK mediated activation of Nedd4-2 during the initial phase of the MDCK cell polarization process