UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database SHP2 signaling: VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) → GAB1/SHP2/PKA/eNOS complex (GAB1-PTPN11-PRKACA-NOS3) (modification, activates)
Lu et al., Proc Natl Acad Sci U S A 2011
Evidence: mutant phenotype, physical interaction
NCI Pathway Database SHP2 signaling: VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) → PKA (PRKACA) (modification, activates) Lu et al., Proc Natl Acad Sci U S A 2011
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) → GAB1/SHP2/PKA/eNOS complex (GAB1-PTPN11-PRKACA-NOS3) (modification, activates)
Lu et al., Proc Natl Acad Sci U S A 2011
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) → PKA (PRKACA) (modification, activates) Lu et al., Proc Natl Acad Sci U S A 2011
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: PKA (PRKACA) → VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) (modification, collaborate)
Meyer et al., Mol Cell Biol 2011
Evidence: mutant phenotype, assay