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GATA4 — PRKACB
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Tremblay et al., Endocrinology 2002
:
We now report that GATA-4 is phosphorylated in MA-10 cells in response to cAMP and in heterologous CV-1 cells,
GATA-4 transcriptional activity is
stimulated by
PKA ... We now report that GATA-4 is phosphorylated in MA-10 cells in response to cAMP and in heterologous CV-1 cells,
GATA-4 transcriptional activity is
stimulated by
PKA
Tremblay et al., J Biol Chem 2003
:
We now show that the rapid phosphorylation of
GATA-4 induced by cAMP in vivo can be
blocked by a
PKA-specific inhibitor but not by mitogen activated protein kinase inhibitors, indicating that GATA-4 is predominantly phosphorylated by PKA in response to cAMP in gonadal cells ... Finally,
PKA dependent phosphorylation of
GATA-4 also led to enhanced recruitment of the CREB binding protein coactivator
Tremblay et al., J Steroid Biochem Mol Biol 2003
:
GATA-4 phosphorylation is
mediated by
PKA