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PRKACB — RAC1

Text-mined interactions from Literome

Rüegg et al., Biochim Biophys Acta 2004 (Neoplasms...) : Endothelial cell COX-2 promotes integrin alphaVbeta3 mediated endothelial cell adhesion, spreading, migration and angiogenesis through the prostaglandin-cAMP-PKA dependent activation of the small GTPase Rac
Howe et al., Proc Natl Acad Sci U S A 2005 : Importantly, inhibition of PKA activity or its ability to interact with A kinase anchoring proteins inhibited the activity of the Rac GTPase within pseudopodia
Goldfinger et al., Circ Res 2008 (Mechanotransduction, Cellular) : Moreover, shear induced localized activation of the small GTPase Rac1 , which specifies the directionality of endothelial alignment, was similarly blocked by PKA inhibitors
Goto et al., Mol Biol Cell 2011 : dbcAMP induced Rac1 activation was principally mediated by protein kinase A (PKA) and Sif- and Tiam1-like exchange factor ( STEF ) /Tiam2
O'Connor et al., Am J Physiol Cell Physiol 2012 : Finally, we find that the regulation of Rac1 and RhoA in response to LPA is differentially regulated by phosphodiesterases, PKA , and phosphatidylinositol 3-kinase, thus supporting their spatially distinct compartmentalization
Frasch et al., Prog Lipid Res 2012 (Inflammation) : In macrophages, this early acting pathway results in PKA dependent augmentation of Rac1 activity via increased production of PGE2 and cAMP
Manchanda et al., Oncogene 2013 (Neurilemmoma) : Further, PKA activation through mutation in Prkar1a is sufficient to initiate Rac1 signaling, with subsequent reduction of Nf2 and schwannomagenesis
Kobayashi et al., Arterioscler Thromb Vasc Biol 2013 : This phenomenon is mediated by cAMP/PKA/Tiam1 dependent Epac1 independent Rac1 activation and subsequent enhancement of adherens junction in endothelial cell
Hohmann et al., Int J Cancer 1989 (Cell Transformation, Neoplastic) : The effect of retinyl acetate ( RAC ) on the activity of cAMP dependent protein kinase (PKA) was studied in mouse 10T1/2 cells