Chang et al., Mol Pharmacol 2004
:
ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant negative PKCalpha ( Lys -- > Arg ), c-Src ( Lys -- > Met ), or STAT1 ( Y701M ) mutants, but not by dominant negative STAT3 ( DN ) mutants
Bolick et al., Arterioscler Thromb Vasc Biol 2006
:
Inhibition of rhoA and PKCalpha significantly reduced NF-kappaB activation, ICAM-1 induction, and monocyte adhesion to aorta