UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database TNF receptor signaling pathway : Atypical PKCs (PRKCI/PRKCZ) → sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF) (modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
NCI Pathway Database TNF receptor signaling pathway : Atypical PKCs (PRKCI/PRKCZ) → sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF) (modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF) → sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF) (modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
NCI Pathway Database TNF receptor signaling pathway : p62 (SQSTM1) → sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF) (modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF) → NF kappa B1/RelA complex (NFKB1-RELA) (modification, activates)
Sanz et al., EMBO J 1999, Leitges et al., Mol Cell 2001
Evidence: mutant phenotype, assay, physical interaction