Gene interactions and pathways from curated databases and text-mining

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PRMT5 — WDR77

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Furuno et al., Biochem Biophys Res Commun 2006 : We show that the MEP50 binds histone H2A selectively among core histones, and mediates transcriptional repression of protein arginine methyltransferase PRMT5 , which is known to methylate H2A and H4
Ho et al., PloS one 2013 : These data support a mechanism in which MEP50 binds substrate and stimulates PRMT5 activity modulated by substrate post-translational modifications