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PTAFR — TYK2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lukashova et al., J Biol Chem 2001
:
G-protein independent
activation of
Tyk2 by the
platelet activating factor receptor ... In addition, when COS-7 cells were transfected with
PAFR and constructs containing PAFR promoter 1, coupled to the luciferase reporter gene, PAF
induced a 3.6-fold increase in promoter activation in the presence of
Tyk2
Lukashova et al., J Immunol 2003
:
Janus kinase 2 activation by the
platelet activating factor receptor ( PAFR ) :
roles of
Tyk2 and PAFR C terminus ... Recently, we have shown that PAF signals through the Janus kinase ( Jak ) /STAT pathway and that
Tyk2 plays an essential role in PAF induced
PAFR promoter 1 activation ... Interestingly, following PAF stimulation, Jak2 coimmunoprecipitated with
PAFR in the
presence of active
Tyk2 , but not with a kinase-inactive Tyk2 mutant, K930I