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HSPB1 — PTEN
Text-mined interactions from Literome
Cayado-Gutiérrez et al., Cell Stress Chaperones 2013
(Breast Neoplasms) :
Downregulation of
Hsp27 ( HSPB1 ) in MCF-7 human breast cancer cells
induces upregulation of
PTEN ... Here, we have examined whether the downregulation of
Hsp27 by siHsp27
affects the
PTEN levels in the MCF-7 human breast cancer cell line ... Downregulation of
Hsp27 stabilized
PTEN protein levels
Alam et al., Neuro Oncol 2013
(Brain Neoplasms...) :
PTEN suppresses SPARC induced pMAPKAPK2 and
inhibits SPARC induced Ser78
HSP27 phosphorylation in glioma ... Therefore, this study determined the
effects of
PTEN expression on SPARC induced expression and phosphorylation of
HSP27 ... In contrast,
PTEN inhibits SPARC induced increases in Ser78
HSP27 phosphorylation relative to total HSP27