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PTGS2 — TCF12
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Howe et al., Cancer Res 1999
(Breast Neoplasms...) :
Expression of the inducible prostaglandin synthase cyclooxygenase-2 appears critical for intestinal tumorigenesis resulting from APC mutation, suggesting that
cyclooxygenase-2 might be a transcriptional
target for
beta-catenin/Tcf complexes
Chen et al., Life Sci 1999
:
These results suggest that the transcriptional regulation of COX-2 expression by NF-kappaB depends upon the types of cells studied and that activation of this
transcription factor alone does not
play an important role in the expression of
COX-2 in rat smooth muscle cells
Yuan et al., Cancer Res 2000
:
Here, we report that a
transcription factor , CCAAT/enhancer binding protein beta ( C/EBPbeta ),
plays a critical role in sPLA2IB induced, receptor mediated
COX-2 gene expression in MC3T3E1 and NIH3T3 cells
Guo et al., J Biol Chem 2001
(Cell Transformation, Neoplastic...) :
Activator protein-1
transcription factor mediates bombesin stimulated
cyclooxygenase-2 expression in intestinal epithelial cells
Meyer-Siegler et al., Mol Med 2001
(Prostatic Neoplasms) :
These data suggest that
COX-2 inhibition
induces NF-kappa beta
transcription factor activation, which subsequently induces pro-inflammatory protein expression ( COX-2 and MIF ) and neuroendocrine differentiation in the LNCaP C4-2b subline
Lee et al., Eur J Neurosci 2004
(Hyperalgesia...) :
Moreover, the
transcription factor , nuclear factor-kappa B (NF-kB),
regulates the expressions of both
COX-2 and dynorphin
Cherukuri et al., Cancer Biol Ther 2005
(Colorectal Neoplasms) :
These results suggest that Se-Met
regulates COX-2 at transcriptional level by modulating the activity of NF-kappaB
transcription factor
Sharma et al., Cancer Res 2005
(Carcinoma, Lewis Lung...) :
Tumor derived
COX-2/PGE2 induced expression of the Treg cell-specific
transcription factor , Foxp3, and increased Treg cell activity
Flora et al., Neuromolecular Med 2006
(Inflammation) :
Tat induced
COX-2 expression was partially
prevented by pyrrolidine dithiocarbamate, a potent antioxidant and an inhibitor of the
transcription factor , nuclear factor kappaB
Vij et al., Am J Respir Cell Mol Biol 2008
(Cystic Fibrosis) :
The inhibition of
Cox-2 signaling
led to down-regulation of the downstream C/EBP homologous protein (CHOP)
transcription factor , resulting in a decrease in IL-8 activation
Rajapakse et al., Immunology 2008
:
The data from the nuclear factor-kappaB (NF-kappaB) promoter gene transfection experiment supported the idea that inhibition of iNOS and
COX-2 is
caused by the down-regulation of their
transcription factor , NF-kappaB
Lee et al., Exp Mol Med 2008
:
Also,
COX-2 overexpression
caused suppression of SOX-9 expression, a major
transcription factor that regulates type II collagen expression, as indicated by the Western blot and RT-PCR
Park et al., Mol Cell Endocrinol 2012
:
The present study investigated the
role of RUNX2
transcription factor in regulating the expression of Runx1,
Ptgs2 , and Tnfaip6 using cultured granulosa cells isolated from PMSG primed immature rats
Chen et al., Am J Physiol 1997
:
The
role of nuclear factor (NF)-kappaB
transcription factor in silica induced cyclooxygenase
(COX) II gene expression was examined in the rat alveolar macrophage cell line NR8383