Chan et al., Endocrinology 2003
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PTHrP and a phorbol ester increased gene expression of the BMP IA receptor, and both enhanced BMP2 dependent increases in promoter activity of the signaling molecule SMAD6 Ionescu et al., J Cell Physiol 2004
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In contrast, PTHrP which activates CREB signaling, blocked the stimulatory effect of BMP-2 on colX and Ihh, but minimally inhibited the stimulatory effect of BMP on Smad6