Gene interactions and pathways from curated databases and text-mining

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PTHLH — SMAD6

Text-mined interactions from Literome

Chan et al., Endocrinology 2003 : PTHrP and a phorbol ester increased gene expression of the BMP IA receptor, and both enhanced BMP2 dependent increases in promoter activity of the signaling molecule SMAD6
Ionescu et al., J Cell Physiol 2004 : In contrast, PTHrP which activates CREB signaling, blocked the stimulatory effect of BMP-2 on colX and Ihh, but minimally inhibited the stimulatory effect of BMP on Smad6