Gene interactions and pathways from curated databases and text-mining

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NPY6R — PTK7

Text-mined interactions from Literome

Zhu et al., Structure 1999 : We report here the high-resolution crystal structures of an activated Lck kinase domain in complex with three structurally distinct ATP-competitive inhibitors : AMP-PNP ( a non-selective, non-hydrolyzable ATP analog ) ; staurosporine ( a potent but non-selective protein kinase inhibitor ) ; and PP2 ( a potent Src family selective protein tyrosine kinase inhibitor )
Ding et al., J Biochem 2000 : The tyrosine phosphorylation of wild-type Syk and mSH2 ( C ) Syk, but not that of mSH2 ( N ), was sensitive to PP2 , a specific inhibitor of Src-family protein-tyrosine kinase
Hinata et al., J Pharmacol Sci 2007 : On the other hand, wortmannin, a phosphatidylinositol 3-kinase (PI3K) inhibitor, inhibited only the NHE dependent pathway, while PP2 , a Src family protein tyrosine kinase inhibitor , inhibited only the NHE independent pathway
Oyaizu et al., Intensive Care Med 2012 (Acute Lung Injury...) : The gene expression profiles and Src protein tyrosine kinase ( PTK ) phosphorylation were studied over time, and PP2 , an Src PTK inhibitor , was intravenously administered 10 min before lung ischemia to determine the role of Src PTK in lung injury