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RAB8A — SETD2

Text-mined interactions from Literome

Park et al., Oncogene 2011 (Breast Neoplasms...) : Mel-18 negatively regulated the HIF-1a expression and its target gene VEGF transcription during both normoxia and hypoxia ... We demonstrated that Mel-18 regulated the HIF-1a expression and activity via the PI3K/Akt pathway
Shin et al., PloS one 2013 (Neovascularization, Pathologic...) : Mechanistically, MEL specifically inhibited the EGF induced HIF-1a expression by suppressing the phosphorylation of ERK, mTOR and p70S6K ... Furthermore, the chromatin immunoprecipitation ( ChIP ) assay revealed that MEL reduced the binding of HIF-1a to the VEGF promoter HRE region ... These results suggest that MEL may inhibit human cervical cancer progression and angiogenesis by inhibiting HIF-1a and VEGF expression