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MMP2 — RAC1

Text-mined interactions from Literome

Zhuge et al., J Biol Chem 2001 (Carcinoma, Squamous Cell...) : Rac1 mediates type I collagen dependent MMP-2 activation ... In this report, we provide evidence that Rac1 , one member of Rho related small GTPases, is a mediator of MMP-2 activation in HT1080 fibrosarcoma cells cultured in three-dimensional collagen gel ( 3D-col ) and that MMP-2 activation is required for Rac1 promoted cell invasion through collagen barrier ... Active Rac1 is sufficient to induce MMP-2 activation in cells cultured in fibrin gel, an extracellular matrix component that does not support MMP-2 activation ... The Rac1 dependent MMP-2 activation occurred in a cell associated fashion and required MMP activities ... The Rac1 dependent MMP-2 activation occurred in a cell associated fashion and required MMP activities
Binker et al., Biochem Biophys Res Commun 2009 (Neoplasm Invasiveness...) : EGF promotes invasion by PANC-1 cells through Rac1/ROS dependent secretion and activation of MMP-2
Chan et al., Cardiovasc Ther 2012 (Diabetes Mellitus) : Under high glucose conditions, simvastatin dose-dependently inhibited VSMC migration, decreased PI3K/Akt pathway activity, reduced c-Raf and Ras expression, increased RhoB but not RhoA, Rac1 , and Cdc2 expression, dose-dependently inhibited MMP-2 , but not MMP-9, activity, and dose-dependently inhibited NF-?B activity
Stallings-Mann et al., Sci Transl Med 2012 (Adenocarcinoma...) : We show that expression of mouse Rac1b in lung epithelial cells of transgenic mice stimulated EMT and spontaneous tumor development and that activation of EMT by MMP induced expression of Rac1b gave rise to lung adenocarcinoma in the transgenic mice through bypassing oncogene induced senescence
Serratì et al., Arthritis Rheum 2013 (Scleroderma, Systemic) : Motility increase required Rac1 activation and RhoA inhibition and was inhibited by an MMP inhibitor