Gene interactions and pathways from curated databases and text-mining

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PREX2 — RAC1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Rosenfeldt et al., FEBS Lett 2004 : P-REX2 promoted increased levels of GTP bound Rac that could be further stimulated by enhancing PI-3K activity
Li et al., Prostaglandins Other Lipid Mediat 2005 : Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate induced Rac1 activation and cell migration in endothelial cells ... Furthermore, we found that P-Rex2b is involved in S1P induced Rac1 activation and cell migration in ECs because siRNA mediated suppression of P-Rex2b expression in ECs diminished Rac1 activation and cell migration in response to S1P