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RAC1 — TSC2

Text-mined interactions from Literome

Goncharova et al., J Cell Biol 2004 : Expression of TSC2 or TSC2-HBD in TSC2-/- cells promoted Rac1 activation, inhibition of Rho, stress fiber disassembly, and focal adhesion remodeling ... Because TSC1 and TSC2 regulate Rho and Rac1 , whose activities are interconnected in a reciprocal fashion, loss of either TSC1 or TSC2 function may result in the deregulation of cell motility and adhesion, which are associated with the pathobiology of TSC and LAM
Ohsawa et al., PloS one 2013 (Cell Transformation, Neoplastic...) : Recent studies have suggested that TSC1 and TSC2 also regulate the activities of Rac1 and Rho, members of the Rho family of small GTPases, and thereby influence the ensuing actin cytoskeletal organization at focal adhesions
Okura et al., Int J Oncol 2013 (Kidney Neoplasms) : Recent studies indicated that the tuberous sclerosis 2 (TSC2) gene product, tuberin , regulates Rac1 activity