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RALA — TERF2IP
Text-mined interactions from Literome
Matsubara et al., Oncogene 1999
:
In COS cells, Ral GDP dissociation stimulator (RalGDS) induced
Ral activation was
stimulated by RasG12V or a
Rap1/Ras chimera in which the N-terminal region of Rap1 was ligated to the C-terminal region of Ras but not by Rap1G12V or a Ras/Rap1 chimera in which the N-terminal region of Ras was ligated to the C-terminal region of Rap1, although RalGDS interacted with these small GTP binding proteins ... These results indicate that Ras recruits RalGDS to the plasma membrane and that the translocated RalGDS induces the activation of
Ral , but that
Rap1 does not
activate Ral due to distinct subcellular localization
Ling et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Activated
Rap1 inhibited GH-stimulated activation of
RalA and subsequent GH-stimulated p44/42 MAP kinase activity and Elk-1 mediated transcription
Wolthuis et al., Mol Cell Biol 1998
:
This activation mechanism correlates with the activation mechanism of the small GTPase
Rap1 , a putative upstream
regulator of
Ral guanine nucleotide exchange factors
Zwartkruis et al., EMBO J 1998
:
In addition, we found that although overexpression of active Rap1 is able to activate the Ral pathway, activation of endogenous
Rap1 in fibroblasts does not
result in
Ral activation