Gene interactions and pathways from curated databases and text-mining

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RALA — TERF2IP

Text-mined interactions from Literome

Matsubara et al., Oncogene 1999 : In COS cells, Ral GDP dissociation stimulator (RalGDS) induced Ral activation was stimulated by RasG12V or a Rap1/Ras chimera in which the N-terminal region of Rap1 was ligated to the C-terminal region of Ras but not by Rap1G12V or a Ras/Rap1 chimera in which the N-terminal region of Ras was ligated to the C-terminal region of Rap1, although RalGDS interacted with these small GTP binding proteins ... These results indicate that Ras recruits RalGDS to the plasma membrane and that the translocated RalGDS induces the activation of Ral , but that Rap1 does not activate Ral due to distinct subcellular localization
Ling et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Activated Rap1 inhibited GH-stimulated activation of RalA and subsequent GH-stimulated p44/42 MAP kinase activity and Elk-1 mediated transcription
Wolthuis et al., Mol Cell Biol 1998 : This activation mechanism correlates with the activation mechanism of the small GTPase Rap1 , a putative upstream regulator of Ral guanine nucleotide exchange factors
Zwartkruis et al., EMBO J 1998 : In addition, we found that although overexpression of active Rap1 is able to activate the Ral pathway, activation of endogenous Rap1 in fibroblasts does not result in Ral activation