Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
RB1
→
FOXO1
(increases, FOXO1 Activity, RB1 Activity)
Evidence: Moreover, the expression of a constitutively activated FOXO1 mutant, incapable of being inactivated by AKT, rapidly triggered cellular senescence along with the activation of Rb, but not p53 (Figure 6D).