Gene interactions and pathways from curated databases and text-mining

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FOXO1 — RB1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: RB1 → FOXO1 (increases, FOXO1 Activity, RB1 Activity)
    Evidence: Moreover, the expression of a constitutively activated FOXO1 mutant, incapable of being inactivated by AKT, rapidly triggered cellular senescence along with the activation of Rb, but not p53 (Figure 6D).