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PTGS2 — RB1

Text-mined interactions from Literome

Naruse et al., Carcinogenesis 2006 (Bone Neoplasms...) : Meloxicam, may have both COX-2 dependent and independent inhibitory actions on osteosarcoma
Park et al., Planta Med 2006 : Inhibitory effects of ginsenoside-Rb1 on activation of the 12-O-tetradecanoylphorbol 13-acetate induced cyclooxygenase-2 promoter ... We studied the inhibitory effects of ginsenoside-Rb1 ( 1 ) on 12-O-tetradecanoylphorbol 13-acetate ( TPA ) -induced transcriptional activation of the cyclooxygenase-2 (COX-2) promoter ... Ginsenoside-Rb1 at 100 microM inhibited TPA induced transcriptional activation of the COX-2 promoter ... In conclusion, ginsenoside-Rb1 inhibits TPA induced COX-2 promoter activity through the nuclear factor interleukin-6 binding site and not through the nuclear factor-kappaB or cAMP-responsive elements
Xu et al., Cancer Res 2006 (Bone Neoplasms...) : To investigate a potential role of COX-2 in osteosarcoma , we overexpressed COX-2 in human osteosarcoma cells
Li et al., Neurochem Res 2008 (Hypoxia, Brain) : Overexpression of COX-2 did not increase expression of cyclin D1 or phosphoretinoblastoma protein (pRb) , or cleavage of caspase 3 suggesting that this cell cycle mechanism does not mediate COX-2 toxicity in this model
Zhao et al., J Exp Clin Cancer Res 2011 (Bone Neoplasms...) : We examined the role of COX-2 in osteosarcoma