Gene interactions and pathways from curated databases and text-mining

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MMP9 — RET

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MMP9 → RET (increases, RET Activity, MMP9 Activity) Okada et al., Surgery 2003*
    Evidence: tyrosine kinase inhibitor Genistein, MEK-1 inhibitor PD98059 and PI3-K inhibitor Wortmannin. Inhibitor experiments showed that the expression and activity of pro MMP-9 was totally inhibited by Genistein and partially by Wortmannin, whereas PD98059 had no effect.