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AKT1 — RETN
Text-mined interactions from Literome
Song et al., Biochem Biophys Res Commun 2002
:
Resistin expression was markedly
suppressed by overexpression of the PI3-kinase p110alpha catalytic subunit and by
Akt
Qi et al., Diabetes 2006
(Insulin Resistance) :
Resistin deficiency
enhanced Akt phosphorylation in muscle and liver and decreased suppressor of cytokine signaling-3 level in muscle, and these changes were reversed by resistin replacement
Nakata et al., Biochem Biophys Res Commun 2007
(Insulin Resistance) :
In addition,
resistin inhibited insulin induced phosphorylation of
Akt in islets as well as other insulin target organs
Zhou et al., FEBS Lett 2007
(Insulin Resistance) :
CM and
resistin both
induce insulin resistance with a robust decrease in insulin stimulated phosphorylation of
Akt and GSK3
Gao et al., J Mol Cell Cardiol 2007
(Disease Models, Animal...) :
Resistin induced
Akt phosphorylation in HL-1 cells was inhibited by wortmannin and triciribine ... In addition to cardiomyocytes,
resistin also
induced Akt phosphorylation in endothelial cells and smooth muscle cells, suggesting that resistin receptors are present in these cells
Park et al., Endocrinology 2008
(Body Weight...) :
Leptin enhanced insulin signaling by potentiating IRS2 -- > Akt pathways, whereas
resistin activated
Akt without augmenting insulin receptor substrate 2 phosphorylation
Singhal et al., J Neurosci 2007
(Insulin Resistance) :
In agreement, central
resistin inhibited
Akt phosphorylation and increased the expression of glucose-6-phosphatase, the enzyme regulating glucose output in the liver
Li et al., Diabetes 2008
(Hyperhomocysteinemia) :
Hcy impaired glucose transport and, particularly, the insulin signaling pathway as shown by decreased insulin stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate (IRS)-1, increased serine phosphorylation of IRS-1, and
inhibited Akt phosphorylation both in vitro and in vivo, and these impairments were accompanied by an increase in
resistin expression
Junkin et al., Am J Physiol Regul Integr Comp Physiol 2009
:
Resistin acutely
impaired insulin stimulated glucose transport and
Akt phosphorylation, but only in the presence of palmitate, implicating a role for altered FA metabolism
Luo et al., Endocrine 2009
(Carcinoma, Hepatocellular...) :
In addition,
resistin inhibited the insulin induced phosphorylation of
Akt independent of AMPK
Maillard et al., Reproduction 2011
:
Finally,
resistin stimulated
AKT and p38-MAPK phosphorylation in both species, ERK1/2-MAPK phosphorylation in rats and had the opposite effect on the AMPK pathway ( P < 0.05 )
Reverchon et al., Fertil Steril 2013
(Infertility, Female) :
In the basal state,
resistin rapidly
stimulates Akt and MAPK ERK1/2 and p38 phosphorylation in primary human GCs