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PTPN11 — RHOA
Pathways - manually collected, often from reviews:
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NCI Pathway Database SHP2 signaling:
RHOA/GTP complex (RHOA)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, activates)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
RHOA/GTP complex (RHOA)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, activates)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
Text-mined interactions from Literome
Cetin et al., Am J Physiol Gastrointest Liver Physiol 2007
(Enterocolitis, Necrotizing) :
Nitric oxide inhibits enterocyte migration through activation of
RhoA-GTPase in a
SHP-2 dependent manner ... Strikingly, inhibition of the protein tyrosine phosphatase
SHP-2 in IEC-6 cells
prevented the activation of
RhoA by NO, restored focal adhesions, and reversed the inhibitory effects of NO on enterocyte migration ... These data indicate that NO impairs mucosal healing by inhibiting enterocyte migration through activation of
RhoA in a
SHP-2 dependent manner and support a possible role for SHP-2 as a therapeutic target in diseases of intestinal inflammation like NEC
Lee et al., J Cell Biol 2008
:
Regulation of
RhoA dependent ROCKII
activation by
Shp2