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FOXO1 — RICTOR
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Partovian et al., Mol Cell 2008
:
Reduced
mTORC2 activity in S4 ( -/- ) endothelial cells
results in decreased
FoxO1/3a and eNOS phosphorylation, decreased endothelial cell size, and increased arterial blood pressure in S4 ( -/- ) mice
Rao et al., Immunity 2012
:
The
Foxo1 inactivation was dependent on mTORC1 kinase, given that blockade of mTORC1 abrogated
mTORC2 mediated Akt ( Ser473 ) kinase phosphorylation, resulting in Foxo1 dependent switch from T-bet to Eomesodermin transcription factor activation and increase in memory precursors