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RNF19A — TNFSF11
Text-mined interactions from Literome
Rahman et al., J Lipid Res 2006
(Bone Resorption) :
CLA also inhibited
RANKL induced activation of mitogen activated protein kinase
p38 but had little effect on c-Jun N-terminal kinase activation
Chen et al., Assay Drug Dev Technol 2006
:
Compound 1 did not inhibit the
RANKL induced activation of a NF-kappaB reporter gene, or
p38 kinase activity, suggesting a mechanism of action downstream of NF-kappaB
Rossa et al., J Interferon Cytokine Res 2006
(MAP Kinase Signaling System) :
MKK3/6-p38 MAPK signaling is
required for IL-1beta and TNF-alpha induced
RANKL expression in bone marrow stromal cells
Rossa et al., J Periodontal Res 2008
(MAP Kinase Signaling System) :
Inhibiting
p38 MAPK prior to lipopolysaccharide stimulation
resulted in a significant decrease of
RANKL mRNA expression
Chen et al., J Biol Chem 2008
:
Importantly, PLCgamma2 deficiency severely impaired RANKL signaling, resulting in marked reduction of
RANKL induced activation of MAPKs,
p38 and JNK, but not ERK