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ROR2 — WNT16

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: WNT16 — ROR2 (interaction, mapped from grid kegg_pathways mint intact)
• STRING interaction: ROR2 — WNT16 (interaction, mapped from grid kegg_pathways mint intact)

Text-mined interactions from Literome

Katoh et al., Int J Mol Med 2007 (Colorectal Neoplasms) : Non-canonical WNT signals, regulated by the interaction of WNT, WNT antagonist, Frizzled and ROR2 , are transduced to JNK, ROCK, PKC, MAP3K7, and NFAT signaling cascades
Mikels et al., J Biol Chem 2009 : To determine whether Ror2 can inhibit canonical Wnt signaling in vivo, we examined the effect of Ror2 loss on the expression of the Wnt reporter Axin2 ( LacZ ), finding increased reporter activity in Ror2 null mice, demonstrating that Ror2 can also inhibit Wnt/beta-catenin signaling in the context of intact tissues
Randall et al., J Orthop Res 2012 : Activation of noncanonical Wnt signaling through overexpression of both the cell-surface Wnt receptor Fzd7 and receptor associated protein Ror2 with addition of recombinant Wnt5a promotes the initiation of columnar architecture of growth plate chondrocytes in vitro, representing an important step toward growth plate regeneration