Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Akcakanat et al., Biochem Biophys Res Commun 2007 : mTORC1 is rapamycin-sensitive, and results in phosphorylation of 4E-BP1 and S6K1
Shen et al., International journal of clinical and experimental pathology 2010 (Carcinoma, Endometrioid...) : mTORC1 and mTORC2 phosphorylatively regulate their respective downstream effectors p70S6K/4EBP1 , and Akt
Ciechomska et al., Oncogene 2013 (Brain Neoplasms...) : Decrease of phosphorylation of 4E-BP1 , p70S6K1 and its downstream target S6 ribosomal protein demonstrate inhibition of mTOR signaling by CsA
Montero et al., Mol Cancer Ther 2012 (Ovarian Neoplasms) : Therefore, mTORC1 probably controls p4E-BP1 along two distinct pathways, one of them sensitive to rapamycin and another insensitive
Marzec et al., PloS one 2011 (Lymphoma, T-Cell, Cutaneous) : mTORC1 activates p70S6kinase 1 (p70S6K1) and inhibits 4E-binding protein 1 (4E-BP1)
Kuang et al., Biochem Biophys Res Commun 2009 (Lymphoma...) : Here, we show that inhibition of mTOR signaling with its specific inhibitor, rapamycin, suppresses normal thymocyte DNA synthesis by downregulating 4EBP1, but not S6K, and that 4EBP1 phosphorylation and cyclin D1 expression are coordinately increased in Atm-/- thymocytes
Prabhu et al., Oncogene 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In this study, we found that both Bcr-Abl and the rapamycin-sensitive mTORC1 complex contribute to the phosphorylation ( inactivation ) of 4E-BP1 , an inhibitor of the eIF4E translation initiation factor
Wang et al., J Biol Chem 2006 : The stimulatory effects of insulin on both 4EBP1 kinase activity and binding occurred rapidly and at physiological concentrations of insulin, and both effects required an intact mTORC1
Chuluunbaatar et al., Genes Dev 2010 (Herpes Simplex) : Viruses producing methyl-7 ( m7 ) GTP capped mRNAs, like Herpes Simplex Virus-1 ( HSV-1 ), stimulate cap dependent translation by activating mTORC1 to inhibit the translational repressor 4E-binding protein 1 (4E-BP1)
Oshiro et al., J Biol Chem 2007 : Overexpressed PRAS40 suppressed the phosphorylation of S6K1 and 4E-BP1 at their rapamycin-sensitive phosphorylation sites, and reciprocally, overexpression of S6K1 or 4E-BP1 suppressed phosphorylation of PRAS40 ( Ser ( 183 ) ) and its binding to raptor
Southgate et al., J Biol Chem 2007 : FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle
Hara et al., Cell 2002 : The binding of raptor to mTOR is necessary for the mTOR catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70alpha ... Partial inhibition of raptor expression by RNA interference ( RNAi ) reduces mTOR catalyzed 4EBP1 phosphorylation in vitro
Wong et al., Biochem Biophys Res Commun 2013 : Thus, we found that inhibiting mTORC1 dependent 4E-BP1 phosphorylation mimics the effect of hypoxia on TXNIP expression
Yip et al., Mol Cell 2010 : Extended incubation with FKBP12-rapamycin compromises the structural integrity of mTORC1 in a stepwise manner, leading us to propose a model in which rapamycin inhibits mTORC1 mediated phosphorylation of 4E-BP1 and S6K1 through different mechanisms
Dunlop et al., Autophagy 2011 : Despite this evidence for heightened mTORC1 kinase activity following ULK1 overexpresssion, mTORC1 mediated phosphorylation of S6K1 and 4E-BP1 is significantly inhibited
Gibbons et al., Semin Oncol 2009 (Neoplasms) : Activated mTORC1 regulates protein synthesis by directly phosphorylating 4E-binding protein 1 (4E-BP1) and p70S6K ( S6K ), translation initiation factors that are important to cap dependent mRNA translation, which increases the level of many proteins that are needed for cell cycle progression, proliferation, angiogenesis, and survival pathways
Schalm et al., Curr Biol 2003 : TOS motif mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
Choo et al., Proc Natl Acad Sci U S A 2008 : This reemerged 4E-BP1 phosphorylation is rapamycin-resistant but still requires mTOR, Raptor , and mTORC1 's activity
Choi et al., J Biol Chem 2003 : Moreover, raptor overexpression enhanced the phosphorylation of wild-type PHAS-I by mTOR but not the phosphorylation of the mutant proteins
Ikenoue et al., Methods Enzymol 2009 : In turn, mTORC1 regulates the activity of the translational machinery by modulating S6 kinase ( S6K ) activity and eIF4E binding protein 1 ( 4E-BP1 ) through direct phosphorylation
Rhein et al., Ann Hematol 2011 (Leukemia, Experimental) : However, Rapamycin did not completely inhibit mTORC1 dependent phosphorylation of 4E-BP1