Gene interactions and pathways from curated databases and text-mining

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FOXO1 — RPTOR

Text-mined interactions from Literome

Southgate et al., J Biol Chem 2007 : FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle ... Using C2C12 mouse myoblasts that stably express inducible FOXO1-ER fusion proteins and transgenic mice that specifically overexpress constitutively active FOXO1 in skeletal muscle ( FOXO ( ++/+ ) ), we show that FOXO1 inhibits mTOR signaling and protein synthesis
Chen et al., Dev Cell 2010 : Activated FoxO1 inhibits mTORC1 by TSC2 dependent and TSC2 independent mechanisms ... Thus, under stress conditions, FoxO inhibits the anabolic activity of mTORC1 , a major consumer of cellular energy, while activating Akt, which increases cellular energy metabolism, thereby maintaining cellular energy homeostasis
Melnik et al., Exp Dermatol 2013 : This hypothesis postulates that antiacne agents either enhance nuclear FoxO activity or inhibit mTORC1