Gene interactions and pathways from curated databases and text-mining

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IL1A — RUNX2

Text-mined interactions from Literome

Mengshol et al., Nucleic Acids Res 2001 (MAP Kinase Signaling System) : IL-1 induces collagenase-3 ( MMP-13 ) promoter activity in stably transfected chondrocytic cells : requirement for Runx-2 and activation by p38 MAPK and JNK pathways ... Constitutive expression of the transcription factor Runx-2 correlated with the ability of a cell type to express MMP-13 and was required for IL-1 induction ; moreover, Runx-2 enhanced IL-1 induction of MMP-13 transcription by synergizing with the p38 MAPK signaling pathway
Pei et al., Osteoarthritis Cartilage 2006 (Chondrosarcoma) : Furthermore, IL-1beta induced the phosphorylation of Runx2 , and this effect was blocked by a p38 kinase inhibitor
Rasheed et al., Arthritis Res Ther 2010 (Osteoarthritis) : In this study we determined the effect of a standardized pomegranate extract ( PE ) on the IL-1ß induced activation of MKK3/6, p38-MAPK isoforms and the activation of transcription factor RUNX-2 in primary human OA chondrocytes
Nokhbehsaim et al., J Orofac Orthop 2010 (Mechanotransduction, Cellular...) : In general, CTS also downregulated the IL1ß induced COL1, ALP, and RUNX2 expression
Sun et al., Eur J Pain 2012 (Chronic Disease...) : CCD induced both mechanical allodynia and thermal hyperalgesia, and increased the expression of TNF-a, IL-1ß , IL-6 and NF-?B