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IL1A — RUNX2
Text-mined interactions from Literome
Mengshol et al., Nucleic Acids Res 2001
(MAP Kinase Signaling System) :
IL-1 induces collagenase-3 ( MMP-13 ) promoter activity in stably transfected chondrocytic cells :
requirement for
Runx-2 and activation by p38 MAPK and JNK pathways ... Constitutive expression of the transcription factor Runx-2 correlated with the ability of a cell type to express MMP-13 and was required for IL-1 induction ; moreover,
Runx-2 enhanced
IL-1 induction of MMP-13 transcription by synergizing with the p38 MAPK signaling pathway
Pei et al., Osteoarthritis Cartilage 2006
(Chondrosarcoma) :
Furthermore,
IL-1beta induced the phosphorylation of
Runx2 , and this effect was blocked by a p38 kinase inhibitor
Rasheed et al., Arthritis Res Ther 2010
(Osteoarthritis) :
In this study we determined the effect of a standardized pomegranate extract ( PE ) on the
IL-1ß induced activation of MKK3/6, p38-MAPK isoforms and the activation of transcription factor
RUNX-2 in primary human OA chondrocytes
Nokhbehsaim et al., J Orofac Orthop 2010
(Mechanotransduction, Cellular...) :
In general, CTS also downregulated the
IL1ß induced COL1, ALP, and
RUNX2 expression
Sun et al., Eur J Pain 2012
(Chronic Disease...) :
CCD induced both mechanical allodynia and thermal hyperalgesia, and
increased the expression of TNF-a,
IL-1ß , IL-6 and NF-?B