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INS — S100A12
Text-mined interactions from Literome
Kogire et al., Pancreas 1991
:
The purpose of this study was to examine the
effects of IAPP and
CGRP on glucose- and carbachol stimulated release of
insulin and pancreatic polypeptide (PP) from the isolated perfused rat pancreas ... At the same concentration, however, IAPP significantly ( p less than 0.05 ) inhibited carbachol stimulated ( 10 ( -7 ) M ) release of
insulin by 30 %, and
CGRP significantly
inhibited carbachol stimulated release of insulin by 33 % when compared with the control group
Hermansen et al., Regul Pept 1990
:
At 0.1 nM,
CGRP inhibited
insulin secretion ( P less than 0.01 ), which was already observed at 2 min after its introduction ... In contrast, at higher dose levels,
CGRP stimulated
insulin secretion
Barakat et al., C R Acad Sci III 1990
(Adenoma, Islet Cell...) :
These results suggest that the
effect of
CGRP on
insulin secretion is due to a direct action on beta cells
Tanaka et al., Exp Clin Endocrinol Diabetes 2013
:
Then, we evaluated the
effect of
CGRP inhibition on
insulin secretion and discovered that CGRP inhibition lead to extend first-phase insulin secretion in an antibody dose dependent manner and nearly plateaued at 10 mg/kg, although the effect was not so large and did n't affect plasma glucose level
Kim et al., Nature protocols 2013
:
We highlight the successful application of this protocol in the discovery that
insulin degrading enzyme (IDE) regulates physiological
calcitonin gene related peptide (CGRP) levels, and we detail the key stages and steps in this approach
Leighton et al., FEBS Lett 1989
:
CGRP-1 inhibited
insulin stimulated glycogen synthesis in both soleus and EDL muscle preparations
Fujimura et al., Pancreas 1988
:
In the present study, we also tested the
effect of
CGRP on gastrin releasing peptide ( GRP ; 10 ( -9 ) M ) - or cholecystokinin ( CCK-8, 10 ( -9 ) M ) -stimulated release of
insulin from isolated rat islets in vitro ... At the lowest concentration of CGRP ( 10 ( -11 ) M ), the inhibitory
effect of
CGRP on CCK-8 stimulated release of
insulin was statistically significant ( p less than 0.05 ) and exceptionally potent ( 65-90 % inhibition ) ... These findings suggest that
CGRP may
play a regulatory role in the release of
insulin
Lewis et al., Mol Cell Endocrinol 1988
:
In the presence of 15 mM glucose, a dose dependent
effect of
CGRP28-37 on the secretion of
insulin was observed, with the size of plaques formed by individual B cells reduced at concentrations of CGRP28-37 between 10 ( -5 ) and 10 ( -11 ) M
Pettersson et al., Regul Pept 1988
:
Therefore, we investigated the
effects of
CGRP on
insulin and glucagon secretion in the rat ... In contrast,
CGRP impaired the plasma
insulin responses to both glucose ( 7 mg/min ; P less than 0.001 ) and arginine ( 8.5 mg/min ; P less than 0.001 ), and inhibited the arginine induced increase in plasma glucagon concentrations ( P less than 0.001 ) ... We have shown in the rat : ( 1 ) that CGRP stimulates basal insulin and glucagon secretion ; ( 2 ) that CGRP inhibits stimulated insulin and glucagon secretion ; ( 3 ) that
CGRP and somatostatin more rapidly
induce a potent inhibitory action on glucose stimulated
insulin secretion when given together ; and ( 4 ) that the alpha 2-adrenoceptor antagonist, yohimbine, counteracts the inhibitory action of CGRP on glucose stimulated insulin secretion
Ishizuka et al., Pancreas 1988
:
CGRP did not
affect the release of
insulin from newborn islet cells, whereas at 10 ( -10 ) M, it reduced the release of insulin from adult islet cells by 66 +/- 4 %
Pettersson et al., Endocr Res 1987
:
When injected alone, neither of them did affect basal plasma glucagon levels but
CGRP reduced basal plasma
insulin levels ...
Insulin secretion stimulated by carbachol was
inhibited by
CGRP ( P less than 0.01 ) but not affected by NPY, whereas terbutaline induced insulin secretion was inhibited by both NPY ( P less than 0.05 ) and CGRP ( P less than 0.01 )
Pettersson et al., Endocrinology 1986
:
The intrapancreatic cellular distribution and
effects on basal and stimulated
insulin secretion of the 37-amino-acid polypeptide,
calcitonin gene related peptide (CGRP) , were investigated in the mouse ... In in vivo experiments,
CGRP was found to
inhibit both basal and stimulated
insulin secretion in the mouse ... At this dose level,
CGRP inhibited the
insulin secretory response to carbachol, leaving that to glucose unaffected ... However, at a higher dose level ( 4.25 nmol/kg ),
CGRP inhibited glucose induced
insulin secretion as well ... We conclude that
CGRP occurs in islet cells and in intrapancreatic nerve fibers of both the mouse and the rat, and
inhibits both basal and stimulated
insulin secretion in vivo in the mouse
Silvestre et al., Biochem Pharmacol 1993
:
Reversal of the inhibitory
effects of
calcitonin gene related peptide (CGRP) and amylin on
insulin secretion by the 8-37 fragment of human CGRP ... We have studied the influence of ( 8-37 ) hCGRP on the
effects of both
CGRP and amylin on
insulin secretion
Parlapiano et al., Riv Eur Sci Med Farmacol 1995
(Diabetes Mellitus, Type 2) :
In this review we examine the possible
role of
CGRP in the development of peripheral insulin resistance and altered
insulin secretion which is characteristic of NIDDM
Silvestre et al., Br J Pharmacol 1996
:
3. Both amylin and
CGRP , at 75 pM, clearly
inhibited glucose induced
insulin release ( by 80 % and by 70 %, respectively )
Rasmussen et al., Pancreas 1998
:
Insulin secretion in response to square-wave increases in glucose concentration to 11 mM was
inhibited dose dependently by
CGRP ; at 10 ( -8 ) M the insulin output decreased by 72+/-9 % ( n = 6 ) ... The present results indicate that
CGRP may be
involved in the regulation of
insulin and glucagon secretion from the porcine pancreas