Gene interactions and pathways from curated databases and text-mining

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INS — S100A12

Text-mined interactions from Literome

Kogire et al., Pancreas 1991 : The purpose of this study was to examine the effects of IAPP and CGRP on glucose- and carbachol stimulated release of insulin and pancreatic polypeptide (PP) from the isolated perfused rat pancreas ... At the same concentration, however, IAPP significantly ( p less than 0.05 ) inhibited carbachol stimulated ( 10 ( -7 ) M ) release of insulin by 30 %, and CGRP significantly inhibited carbachol stimulated release of insulin by 33 % when compared with the control group
Hermansen et al., Regul Pept 1990 : At 0.1 nM, CGRP inhibited insulin secretion ( P less than 0.01 ), which was already observed at 2 min after its introduction ... In contrast, at higher dose levels, CGRP stimulated insulin secretion
Barakat et al., C R Acad Sci III 1990 (Adenoma, Islet Cell...) : These results suggest that the effect of CGRP on insulin secretion is due to a direct action on beta cells
Tanaka et al., Exp Clin Endocrinol Diabetes 2013 : Then, we evaluated the effect of CGRP inhibition on insulin secretion and discovered that CGRP inhibition lead to extend first-phase insulin secretion in an antibody dose dependent manner and nearly plateaued at 10 mg/kg, although the effect was not so large and did n't affect plasma glucose level
Kim et al., Nature protocols 2013 : We highlight the successful application of this protocol in the discovery that insulin degrading enzyme (IDE) regulates physiological calcitonin gene related peptide (CGRP) levels, and we detail the key stages and steps in this approach
Leighton et al., FEBS Lett 1989 : CGRP-1 inhibited insulin stimulated glycogen synthesis in both soleus and EDL muscle preparations
Fujimura et al., Pancreas 1988 : In the present study, we also tested the effect of CGRP on gastrin releasing peptide ( GRP ; 10 ( -9 ) M ) - or cholecystokinin ( CCK-8, 10 ( -9 ) M ) -stimulated release of insulin from isolated rat islets in vitro ... At the lowest concentration of CGRP ( 10 ( -11 ) M ), the inhibitory effect of CGRP on CCK-8 stimulated release of insulin was statistically significant ( p less than 0.05 ) and exceptionally potent ( 65-90 % inhibition ) ... These findings suggest that CGRP may play a regulatory role in the release of insulin
Lewis et al., Mol Cell Endocrinol 1988 : In the presence of 15 mM glucose, a dose dependent effect of CGRP28-37 on the secretion of insulin was observed, with the size of plaques formed by individual B cells reduced at concentrations of CGRP28-37 between 10 ( -5 ) and 10 ( -11 ) M
Pettersson et al., Regul Pept 1988 : Therefore, we investigated the effects of CGRP on insulin and glucagon secretion in the rat ... In contrast, CGRP impaired the plasma insulin responses to both glucose ( 7 mg/min ; P less than 0.001 ) and arginine ( 8.5 mg/min ; P less than 0.001 ), and inhibited the arginine induced increase in plasma glucagon concentrations ( P less than 0.001 ) ... We have shown in the rat : ( 1 ) that CGRP stimulates basal insulin and glucagon secretion ; ( 2 ) that CGRP inhibits stimulated insulin and glucagon secretion ; ( 3 ) that CGRP and somatostatin more rapidly induce a potent inhibitory action on glucose stimulated insulin secretion when given together ; and ( 4 ) that the alpha 2-adrenoceptor antagonist, yohimbine, counteracts the inhibitory action of CGRP on glucose stimulated insulin secretion
Ishizuka et al., Pancreas 1988 : CGRP did not affect the release of insulin from newborn islet cells, whereas at 10 ( -10 ) M, it reduced the release of insulin from adult islet cells by 66 +/- 4 %
Pettersson et al., Endocr Res 1987 : When injected alone, neither of them did affect basal plasma glucagon levels but CGRP reduced basal plasma insulin levels ... Insulin secretion stimulated by carbachol was inhibited by CGRP ( P less than 0.01 ) but not affected by NPY, whereas terbutaline induced insulin secretion was inhibited by both NPY ( P less than 0.05 ) and CGRP ( P less than 0.01 )
Pettersson et al., Endocrinology 1986 : The intrapancreatic cellular distribution and effects on basal and stimulated insulin secretion of the 37-amino-acid polypeptide, calcitonin gene related peptide (CGRP) , were investigated in the mouse ... In in vivo experiments, CGRP was found to inhibit both basal and stimulated insulin secretion in the mouse ... At this dose level, CGRP inhibited the insulin secretory response to carbachol, leaving that to glucose unaffected ... However, at a higher dose level ( 4.25 nmol/kg ), CGRP inhibited glucose induced insulin secretion as well ... We conclude that CGRP occurs in islet cells and in intrapancreatic nerve fibers of both the mouse and the rat, and inhibits both basal and stimulated insulin secretion in vivo in the mouse
Silvestre et al., Biochem Pharmacol 1993 : Reversal of the inhibitory effects of calcitonin gene related peptide (CGRP) and amylin on insulin secretion by the 8-37 fragment of human CGRP ... We have studied the influence of ( 8-37 ) hCGRP on the effects of both CGRP and amylin on insulin secretion
Parlapiano et al., Riv Eur Sci Med Farmacol 1995 (Diabetes Mellitus, Type 2) : In this review we examine the possible role of CGRP in the development of peripheral insulin resistance and altered insulin secretion which is characteristic of NIDDM
Silvestre et al., Br J Pharmacol 1996 : 3. Both amylin and CGRP , at 75 pM, clearly inhibited glucose induced insulin release ( by 80 % and by 70 %, respectively )
Rasmussen et al., Pancreas 1998 : Insulin secretion in response to square-wave increases in glucose concentration to 11 mM was inhibited dose dependently by CGRP ; at 10 ( -8 ) M the insulin output decreased by 72+/-9 % ( n = 6 ) ... The present results indicate that CGRP may be involved in the regulation of insulin and glucagon secretion from the porcine pancreas