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IL1A — SAA3P
Text-mined interactions from Literome
Huang et al., J Interferon Cytokine Res 1999
:
Our results indicate that synergistic
activation of
SAA3 promoter by
IL-1 and IL-6 is achieved through integration of signals triggered by these two cytokines onto the DRE and that all three functionally distinct regulatory elements in the DRE are required to effectively and fully activate SAA3 gene transcription
Sommer et al., J Cell Biochem 2008
:
Furthermore,
IL-1beta significantly
induced SAA3 mRNA expression dose-dependently with maximal 36.4-fold upregulation seen at 2 ng/ml effector ... Moreover,
IL-1beta induced
SAA3 expression was mediated by nuclear factor-kappaB and janus kinase 2
Shimizu et al., Gene 1994
(Inflammation) :
We demonstrate that the expression of one of SAA genes ( SAA3 ) is induced by interleukin-1 (IL-1), and that other inflammatory cytokines such as IL-6 and leukemia inhibitory factor, while they themselves are without any effects, enhanced
IL-1 induced
SAA3 gene expression