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ADCYAP1 — SCG2

Text-mined interactions from Literome

Turquier et al., Mol Pharmacol 2001 : The effect of PACAP on both SN secretion and SgII mRNA levels is rapid and long lasting ... Inhibition of protein kinase A (PKA) or C ( PKC ) also reduced PACAP evoked SN release but did not alter the stimulatory effect of PACAP on SgII mRNA levels ... Conversely, application of mitogen activated protein kinase inhibitors suppressed PACAP induced SgII gene expression ... The effect of PACAP on SgII mRNA levels, like the effect of the PKC stimulator 12-O-tetradecanoylphorbol-13-acetate ( TPA ), was not affected by cycloheximide, whereas the effects of the PKA stimulator forskolin or cell-depolarization by high K ( + ) were significantly reduced by the protein synthesis inhibitor
Guillemot et al., Regul Pept 2006 : It has been shown that PACAP regulates SgII gene transcription and SN release in bovine adrenochromaffin cells ... These results indicate that, in bovine adrenal medulla, SgII is processed to generate the EM66 peptide and that PACAP activates multiple signaling pathways to regulate EM66 release from chromaffin cells, suggesting that EM66 may act downstream of the trans-synaptic stimulation of the adrenal medulla by neurocrine factors