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IL10 — SEA
Text-mined interactions from Literome
Velupillai et al., Hum Immunol 2000
(Schistosomiasis mansoni) :
Soluble egg antigens (SEA) also
induced IL-10 production by PBMC from infected patients ... Interestingly, the
SEA induced
IL-10 production was remarkably inhibited by pretreatment of PBMC with free ligands of LNFPIII ( monovalent form )
Farah et al., Scand J Immunol 2000
(Granuloma...) :
Group B animals had low SEA induced IFN-gamma levels and elevated IL-5 levels, although these were lower than group C.
SEA induced
IL-10 was low in both groups A and B as compared to group C ( P < 0.01 )
Hegardt et al., Cell Immunol 2000
(Disease Progression...) :
Plastic adherent spleen cells from tumor bearing rats suppressed the
SEA induced proliferative response and the production of IFN-gamma and
IL-10 by nonadherent spleen cells from tumor-free rats
Tangsinmankong et al., Cytokine 2000
:
By contrast,
SEA induced
IL-10 production as well as mRNA expression using T lymphocytes but not with monocytes or B lymphocytes
King et al., Parasite Immunol 2001
(Schistosomiasis mansoni) :
By contrast, CD4+ splenocytes produced comparatively little cytokine release by endogenous antigen, whereas exogenous
SEA strongly
induced IL-4, IL-5,
IL-10 and IFN-gamma production and lymphocyte proliferation that correlated poorly with the dynamics of granulomatous inflammation
Tangsinmankong et al., Immunol Lett 2002
:
Recently, we demonstrated that HIV-1 Nef induces
IL-10 production in monocytes and that
staphylococcal enterotoxin A (SEA) induces IL-10 production in T-lymphocytes ... Conversely, we show that CsA and FK506 completely inhibit
SEA induced
IL-10 protein production and mRNA expression
Ramos et al., Mem Inst Oswaldo Cruz 2006
(Disease Models, Animal...) :
Interleukins, IL-4 and
IL-10 responses to
soluble egg antigens (SEA) 90 days after infection, were determined
Huang et al., Acta Biochim Biophys Sin (Shanghai) 2007
:
Repeated
SEA stimulation
led to down-regulation of interleukin (IL)-2, and high levels of
IL-10
Rutitzky et al., J Immunol 2008
(Liver Diseases, Parasitic...) :
We now show that mice lacking the IL-23-specific subunit p19 are impaired in developing severe immunopathology following immunization with SEA/CFA, which is associated with a marked drop of IL-17 in the granulomas, but not in the draining mesenteric lymph nodes, and with a markedly suppressed
SEA-specific IFN-gamma response
regulated by a striking increase in
IL-10
Correale et al., J Immunol 2009
(Multiple Sclerosis...) :
SEA suppressed the LPS induced DCs production of IL-1beta, IL-6, IL-12, and TNF-alpha and
enhanced TGF-beta as well as
IL-10 production
Ferreira et al., Mem Inst Oswaldo Cruz 2012
(Chronic Disease...) :
We demonstrate that stimulation with
SEA induced prominent lymphocyte proliferation and high levels of tumour necrosis factor (TNF)-a,
interleukin (IL)-4 and IL-10 secretion in both OST and non infected individuals ( NI )
da Silva et al., TheScientificWorldJournal 2012
(Schistosomiasis mansoni) :
Histopathological analysis of liver tissue showed changes in morphological aspects of the hepatic parenchyma with decrease exudative-productive hepatic granuloma stages, although we found no significant differences in IFN-?, IL-4,
IL-10 , or NO production in
response to the specific antigen
SEA
Boghdadi et al., Parasitol Res 2013
(Liver Cirrhosis...) :
Levels of interferon-? ( IFN-? ), interleukin 4 (IL-4),
IL-10 , and IL-13 were measured by ELISA in the supernatants of cultured peripheral blood mononuclear cells ( PBMC ) in
response to schistosoma egg
soluble antigen (SEA) in the presence and absence of R848
Tang et al., PloS one 2012
:
The production of
IL-10 and IL-6 in RAW 264.7 cells,
induced by
SEA , was responsible for mediating the down-regulation of MHC class II ... Our findings suggest that in RAW 264.7 cells ( 1 ) IFN-? provides a condition for lower concentrations of SEA to attenuate MHC class II expression ; ( 2 ) SEA attenuated IFN-? induced MHC class II expression and the
IL-10 and IL-6 production is mediated at least partly by the interaction of SEA with TLR4 ; and ( 3 )
SEA attenuated IFN-? induced MHC class II expression at the transcriptional level
King et al., J Immunol 1996
(Chronic Disease...) :
SWAP or
SEA triggered
IL-10 release from PBMC of both patients and healthy individuals ; however, CD4+ cells were a significant source of IL-10 only in infected subjects
Hobeika et al., Biochem Biophys Res Commun 1996
:
A synthetic peptide of this region, SEA ( 121-149 ), blocks
SEA binding to class II MHC molecules and
induces interleukin-1 and tumor necrosis factor production in monocytes
Sundstedt et al., J Immunol 1997
:
Depletion of T cells with anti-CD4 or anti-CD8 mAb indicated that CD4+ T cells were crucial for
SEA induced
IL-10 production
Bosshardt et al., Parasite Immunol 1997
(Chronic Disease...) :
In contrast, while
SEA stimulated
IL-10 production was again highest with cells from mice with acute infections, spleen cells from mice with MSS produced significantly more IL-10 than did those from mice with HSS