◀ Back to CDKN1A

CDKN1A — SEC14L2

Text-mined interactions from Literome

Million et al., Int J Oncol 2006 (Neuroblastoma) : In the presence of cisplatin, exogenous TAp73 overexpression in SH-SY5Y cells induced p21 up-regulation without altering the apoptotic sub-G1 cell population
Gallegos et al., J Biol Chem 2008 : This stabilization of TAp63gamma leads to up-regulation of p21 at the mRNA and protein level by increased binding of TAp63gamma at the p21 promoter
Soond et al., Cell cycle (Georgetown, Tex.) 2008 (Cell Transformation, Neoplastic) : Using reporter assays and Electrophoretic Mobility Shift Assays ( EMSA ), our findings suggest that TAp73 mediated activation of the p21 ( cip/waf ), 14-3-3sigma and Bax gene promoters is abrogated by expressed PLK1 for which post-translational modification of TAp73 Thr-27 appears to be a key step in MCF7 cells
Guo et al., Nat Cell Biol 2009 (Cell Transformation, Neoplastic) : TAp63 induces senescence independently of p53, p19(Arf) and p16(Ink4a), but requires p21 ( Waf/Cip1 ) and Rb. TAp63 mediated senescence overrides Ras-driven transformation of p53-deficient cells, preventing tumour initiation, and doxycycline regulated expression of TAp63 activates p21 ( Waf/Cip1 ), induces senescence and inhibits progression of established tumours in vivo
Heyne et al., Nucleic Acids Res 2010 : Conversely, knockdown of NIR by RNAi stimulated p21 transcription in the presence of TAp63