Gene interactions and pathways from curated databases and text-mining

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FOXO1 — SELL

Text-mined interactions from Literome

Fabre et al., J Immunol 2008 : FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase ... We now report that FOXO1 controls the expression of L-selectin , an essential homing molecule, in human T lymphocytes
Kerdiles et al., Nat Immunol 2009 : In naive T cells, Foxo1 controlled the expression of the adhesion molecule L-selectin , the chemokine receptor CCR7 and the transcription factor Klf2, and its deletion was sufficient to alter lymphocyte trafficking
Kittipatarin et al., Exp Hematol 2010 : We found that IL-7 prevented the nuclear translocation of the transcription factor, Foxo1 , in a manner dependent on the activity of Cdc25A, resulting in decreased levels of CD62L
Lou et al., Gene regulation and systems biology 2012 : Significantly, FOXO1 binds to a FOXO1 motif, CCCTTTGG, at -87/-80, and transactivates the L-selectin promoter in a dose dependent manner ... Significantly, FOXO1 binds to a FOXO1 motif, CCCTTTGG, at -87/-80, and transactivates the L-selectin promoter in a dose dependent manner ... Over-expression of a constitutive-active FOXO1 increased the endogenous L-selectin expression in Jurkat cells ... We conclude that FOXO1 regulates L-selectin expression through targeting its promoter