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FOXO1 — SELL
Text-mined interactions from Literome
Fabre et al., J Immunol 2008
:
FOXO1 regulates
L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase ... We now report that
FOXO1 controls the expression of
L-selectin , an essential homing molecule, in human T lymphocytes
Kerdiles et al., Nat Immunol 2009
:
In naive T cells,
Foxo1 controlled the expression of the adhesion molecule
L-selectin , the chemokine receptor CCR7 and the transcription factor Klf2, and its deletion was sufficient to alter lymphocyte trafficking
Kittipatarin et al., Exp Hematol 2010
:
We found that IL-7 prevented the nuclear translocation of the transcription factor,
Foxo1 , in a manner dependent on the activity of Cdc25A, resulting in decreased
levels of
CD62L
Lou et al., Gene regulation and systems biology 2012
:
Significantly,
FOXO1 binds to a FOXO1 motif, CCCTTTGG, at -87/-80, and
transactivates the
L-selectin promoter in a dose dependent manner ... Significantly,
FOXO1 binds to a FOXO1 motif, CCCTTTGG, at -87/-80, and
transactivates the
L-selectin promoter in a dose dependent manner ... Over-expression of a constitutive-active
FOXO1 increased the endogenous
L-selectin expression in Jurkat cells ... We conclude that
FOXO1 regulates
L-selectin expression through targeting its promoter