Gene interactions and pathways from curated databases and text-mining

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FOXO1 — SERPINE1

Text-mined interactions from Literome

Jung et al., Biochem Biophys Res Commun 2009 (Hyperinsulinism) : Here, we examined whether adenoviral mediated expression of a constitutively active form of FoxO1 ( Ad-CA-FoxO1 ) inhibited insulin stimulated PAI-1 expression in human HepG2 hepatocellular liver carcinoma cells and mouse AML12 hepatocytes ... Transient transfection assays using a reporter gene under the control of the PAI-1 promoter revealed that CA-FoxO1 inhibits Smad3 stimulated PAI-1 promoter activity ... Taken together, our results indicate that FoxO1 inhibits PAI-1 expression through the inhibition of TGF-beta/Smad mediated signaling pathways
Jag et al., Mol Endocrinol 2009 : Here we demonstrate that overexpression of Forkhead related transcription factor ( Fox)O1 , FoxO3a, and FoxC1 augment insulin 's ability to activate the PAI-1 promoter