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FOXO1 — SERPINE1
Text-mined interactions from Literome
Jung et al., Biochem Biophys Res Commun 2009
(Hyperinsulinism) :
Here, we examined whether adenoviral mediated expression of a constitutively active form of
FoxO1 ( Ad-CA-FoxO1 )
inhibited insulin stimulated
PAI-1 expression in human HepG2 hepatocellular liver carcinoma cells and mouse AML12 hepatocytes ... Transient transfection assays using a reporter gene under the control of the PAI-1 promoter revealed that
CA-FoxO1 inhibits Smad3 stimulated
PAI-1 promoter activity ... Taken together, our results indicate that
FoxO1 inhibits
PAI-1 expression through the inhibition of TGF-beta/Smad mediated signaling pathways
Jag et al., Mol Endocrinol 2009
:
Here we demonstrate that overexpression of Forkhead related transcription factor (
Fox)O1 , FoxO3a, and FoxC1 augment insulin 's ability to
activate the
PAI-1 promoter