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RHO — SERPINE1
Text-mined interactions from Literome
Takeda et al., Arterioscler Thromb Vasc Biol 2001
(MAP Kinase Signaling System) :
Adenovirus mediated overexpression of the dominant negative form of
Rho-kinase or Y27632, a Rho-kinase inhibitor, also completely
prevented PAI-1 induction by Ang II without affecting Ang II-induced ERK activation
Ishibashi et al., Biochim Biophys Acta 2002
(Arteriosclerosis) :
Moreover,
Rho-kinase inhibitors, Y-27632 and fasudil,
suppressed the synthesis of
PAI-1 in this culture system
Goto et al., Biochem Pharmacol 2003
(Obesity) :
The
Rho-kinase inhibitor, Y-27632 [ ( R ) - ( + ) -trans-N- ( 4-pyridyl ) -4- ( 1-aminoethyl ) -cyclohexanecarboxamide ],
increased PAI-1 expression markedly
Rikitake et al., Circulation 2005
(Hyperglycemia) :
The mechanism for this inhibition occurs at the level of gene transcription because
Rho-kinase inhibitors
repress hyperglycemia stimulated
PAI-1 promoter activity without affecting mRNA stability
Bryan et al., Mol Cancer Res 2008
(Brain Neoplasms...) :
Accordingly, the inhibition of mitogen activated protein kinase/extracellular signal regulated kinase kinase 1/2 and
Rho-kinase , two downstream signaling cascades activated by S1P(2),
blocked the activation of
PAI-1 and uPAR mRNA expression by S1P