Gene interactions and pathways from curated databases and text-mining

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RHO — SERPINE1

Text-mined interactions from Literome

Takeda et al., Arterioscler Thromb Vasc Biol 2001 (MAP Kinase Signaling System) : Adenovirus mediated overexpression of the dominant negative form of Rho-kinase or Y27632, a Rho-kinase inhibitor, also completely prevented PAI-1 induction by Ang II without affecting Ang II-induced ERK activation
Ishibashi et al., Biochim Biophys Acta 2002 (Arteriosclerosis) : Moreover, Rho-kinase inhibitors, Y-27632 and fasudil, suppressed the synthesis of PAI-1 in this culture system
Goto et al., Biochem Pharmacol 2003 (Obesity) : The Rho-kinase inhibitor, Y-27632 [ ( R ) - ( + ) -trans-N- ( 4-pyridyl ) -4- ( 1-aminoethyl ) -cyclohexanecarboxamide ], increased PAI-1 expression markedly
Rikitake et al., Circulation 2005 (Hyperglycemia) : The mechanism for this inhibition occurs at the level of gene transcription because Rho-kinase inhibitors repress hyperglycemia stimulated PAI-1 promoter activity without affecting mRNA stability
Bryan et al., Mol Cancer Res 2008 (Brain Neoplasms...) : Accordingly, the inhibition of mitogen activated protein kinase/extracellular signal regulated kinase kinase 1/2 and Rho-kinase , two downstream signaling cascades activated by S1P(2), blocked the activation of PAI-1 and uPAR mRNA expression by S1P