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SFRP4 — WNT16
Pathways - manually collected, often from reviews:
-
KEGG Wnt signaling pathway:
SFRP1/SFRP2/SFRP4/SFRP5
→
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
(protein-protein, inhibition)
Text-mined interactions from Literome
La et al., Di Yi Jun Yi Da Xue Xue Bao 2004
(Liver Neoplasms) :
[ Anti-oncogene p53 induced expression of
secreted frizzled related protein , a
Wnt signaling
inhibitor ]
He et al., Cancer Res 2005
(Mesothelioma) :
Our results suggest that methylation silencing of
SFRP4 may
play an important role in aberrant
Wnt activation in mesothelioma even in the absence of beta-catenin
Marsit et al., Cancer Res 2005
(Disease Progression...) :
Epigenetic silencing of the secreted frizzled receptor proteins (
SFRP ), antagonists of the WNT pathway,
leads to constitutive
WNT signaling, altering cell morphology and motility
Rodriguez et al., Nat Neurosci 2005
:
Here we show that
secreted Frizzled related protein 1 ( SFRP1 ), a proposed
Wnt signaling
inhibitor , can directly modify and reorient the growth of chick and Xenopus laevis retinal ganglion cell axons
Zi et al., Cancer Res 2005
(Neoplasm Invasiveness...) :
The ability of
Frzb/secreted Frizzled related protein 3 ( sFRP3 ) to
inhibit Wnt signaling and the localization of Frzb/sFRP3 on chromosome 2q to a region frequently deleted in cancers have led some investigators to hypothesize that Frzb/sFRP3 is a tumor suppressor gene
Nojima et al., Oncogene 2007
(Carcinoma...) :
Frequent epigenetic inactivation of
SFRP genes and constitutive
activation of
Wnt signaling in gastric cancer
Gumz et al., Clin Cancer Res 2007
(Carcinoma, Renal Cell...) :
In an effort to gain a better understanding of signaling events in clear cell RCC ( cRCC ), we investigated the antitumor activity of
secreted frizzled related protein 1 ( sFRP1 ), a negative
regulator of
Wnt signaling
Schlange et al., Breast Cancer Res 2007
(Breast Neoplasms) :
Most breast tumors show hypermethylation of the promoter region of
secreted Frizzled related protein 1 ( sFRP1 ), a negative
WNT pathway
regulator , leading to downregulation of its expression
Bayle et al., J Invest Dermatol 2008
(Scleroderma, Systemic) :
Increased expression of Wnt2 and
SFRP4 in Tsk mouse skin :
role of
Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis
Dufourcq et al., Am J Pathol 2008
(Neovascularization, Pathologic) :
Our previous work has shown a role for
secreted Frizzled related protein-1 ( sFRP-1 ), a proposed
Wnt signaling
inhibitor , in neovascularization after an ischemic event and demonstrated its role as a potent angiogenic factor
Trenkmann et al., Ann Rheum Dis 2011
(Arthritis, Rheumatoid) :
As a target gene of EZH2 the authors identified
secreted frizzled related protein 1 ( SFRP1 ), an
inhibitor of
Wnt signalling, which is associated with the activation of RASF, and show that SFRP1 expression correlates with the occupation of its promoter with activating and silencing histone marks
Froeling et al., Gastroenterology 2011
(Carcinoma, Pancreatic Ductal...) :
Restoring
secreted frizzled related protein 4 ( sFRP4 ) secretion to quiescent PSCs
reduced Wnt-ß-catenin signaling in cancer cells and their invasive ability
Mao et al., Invest Ophthalmol Vis Sci 2012
(Wnt Signaling Pathway) :
We previously discovered elevated levels of
secreted frizzled related protein 1 ( sFRP1 ), the
Wnt signaling pathway
inhibitor , in the glaucomatous trabecular meshwork ( GTM ), and found that key canonical Wnt signaling pathway genes are expressed in the trabecular meshwork ( TM )
Shen et al., PloS one 2012
:
Such a loss was averted by treatment of
secreted Frizzled related protein 1 ( sFRP1 ), an
inhibitor of
Wnt signaling
Yamada et al., Biomaterials 2013
(Wnt Signaling Pathway) :
In addition,
SFRP3 inhibited non-canonical
WNT signalling by binding WNT5A, which is a representative non-canonical WNT protein