◀ Back to VEGFA

SHH — VEGFA

Text-mined interactions from Literome

Fu et al., Acta Pharmacol Sin 2006 : Sonic hedgehog protein promotes bone marrow derived endothelial progenitor cell proliferation, migration and VEGF production via PI 3-kinase/Akt signaling pathways ... To investigate the effects of Sonic hedgehog (shh) protein on bone marrow- derived endothelial progenitor cells ( BM-EPC ) proliferation, migration and vascular endothelial growth factor ( VEGF ) production, and the potential signaling pathways involved in these effects ... Moreover, the inhibitor of the PI3-kinase, but not the inhibitor of the PKC, significantly inhibited the shh mediated proliferation, migration and VEGF production
White et al., Development 2007 : FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network ... These data suggest a molecular mechanism through which FGF9 and SHH signaling coordinately control the growth and patterning of the lung capillary plexus, and regulate the temporal and spatial expression of Vegfa
de Mooij et al., Prenat Diagn 2009 (Down Syndrome) : We hypothesized that abnormal Sonic hedgehog (Shh) expression would result in altered VEGF-A signaling in the lymphatic endothelial cells of the JLS and that aberrant acquisition of SMCs could be caused by downregulation of forkhead transcription factor FOXC2 and upregulation of platelet derived growth factor (PDGF)-B in the lymphatic endothelial cells of the JLS
Dormoy et al., Molecular cancer 2009 (Carcinoma, Renal Cell...) : Gli1, cyclin D1, Pax2, Lim1, VEGF , and TGF-beta were exclusively expressed in tumors and were shown to be regulated by SHH , as evidenced by immunoblot after SHH inhibition
Fujii et al., In Vitro Cell Dev Biol Anim 2010 : Shh enhanced Ang-1 expression but did not enhance vascular endothelial growth factor in fibroblasts
Li et al., Mol Neurobiol 2013 (Disease Models, Animal) : The results of silencing Gli-1, or NR2F2, exhibited that exogenous Shh could regulate the expressions of VEGF , Ang-1, and Ang-2 in astrocytes by activating the NR2F2, but not the Gli-1